4-benzenesulfonyloxy-2-nitrotoluene

Base Information

• Chemical Name: 4-benzenesulfonyloxy-2-nitrotoluene
• CAS No.: 92059-54-6
• Molecular Formula: C₁₃H₁₁NO₅S
• Molecular Weight: 293.3
• Mol file: 92059-54-6.mol

Synonyms:4-benzenesulfonyloxy-2-nitrotoluene

Chemical Property of 4-benzenesulfonyloxy-2-nitrotoluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzenesulfonyloxy-2-nitrotoluene

There total 2 articles about 4-benzenesulfonyloxy-2-nitrotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-5-nitrophenol (2042-14-0) + benzenesulfonyl chloride (98-09-9) → 4-benzenesulfonyloxy-2-nitrotoluene (92059-54-6)

Guidance literature:

With potassium carbonate; In acetone; for 2h;

DOI:10.1080/00397919408011708

Reference yield:

→ 4-benzenesulfonyloxy-2-nitrotoluene (92059-54-6)

Guidance literature:

2-Nitro-4-hydroxy-toluol, Benzoesulfonsaeurechlorid, W., Na2CO3, 95-100grad;

Reference yield:

4-benzenesulfonyloxy-2-nitrotoluene (92059-54-6) → N,N-di-n-propyl-(1-benzenesulfonyl-6-benzenesulfonyloxy-5-indolinyl)-acetamide (155636-52-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 2.) TiCl₃, ammonium acetate / 1.) DMF, 120 deg C, 5 h, 2.) MeOH, 10 min

2: NaBH₃CN, acetic acid / 4 h / Ambient temperature

3: Et₃N / acetic acid / 1 h

4: 1.) TFAA, 2.) SnCl₄ / 1.) CH₂Cl₂, 20 min, 2.) CH₂Cl₂, RT, overnight

5: 100 percent / Raney-Ni / ethanol / 2 h

With ammonium acetate; titanium(III) chloride; tin(IV) chloride; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic anhydride; nickel; In ethanol; acetic acid;

DOI:10.1080/00397919408011708

upstream raw materials:

4-methyl-5-nitrophenol

benzenesulfonyl chloride

Downstream raw materials:

Benzenesulfonic acid 2,3-dihydro-1H-indol-6-yl ester

1-benzenesulfonyl-6-benzenesulfonyloxyindoline

N,N-di-n-propyl-(1-benzenesulfonyl-6-benzenesulfonyloxy-5-indolinyl)-acetamide

N,N-di-n-propyl-(p-chlorophenylthio)-(1-benzenesulfonyl-6-benzenesulfonyloxy-5-indolinyl)-acetamide