3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Chemical Name:3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine
CAS No.:1201787-99-6
Molecular Formula:C₂₃H₁₇IN₄O₃S
Molecular Weight:556.383
Hs Code.:

Synonyms:3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Chemical Property of 3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

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Technology Process of 3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

There total 12 articles about 3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1201787-98-5
3-methoxy-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201787-99-6
3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: 3-methoxy-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; for 0.166667h; Inert atmosphere;

Reference yield:

: 183741-80-2
tert-butyl N-(6-methoxypyridin-3-yl)carbamate

: 1201787-99-6
3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert.-butyl lithium / pentane; tetrahydrofuran / 3.25 h / -78 - -10 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h

4.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

6.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

6.2: 0.17 h / Inert atmosphere

With hydrogenchloride; n-butyllithium; potassium tert-butylate; tert.-butyl lithium; sodium hydride; diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; N,N-dimethyl-formamide; pentane;

Reference yield:

: 16110-09-1
2,5 dichloropyridine

: 1201787-99-6
3-methoxy-4-iodo-6-pyrid-3-yl-9-(toluene-4-sulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 125 °C / Microwave irradiation

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / 1,4-dioxane / 1 h / 150 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h

5.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

6.1: sodium hydride / N,N-dimethyl-formamide / 2 h / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

7.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

7.2: 0.17 h / Inert atmosphere

With hydrogenchloride; n-butyllithium; potassium tert-butylate; sodium hydride; caesium carbonate; diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide;