(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

Base Information

Chemical Name:(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide
CAS No.:131654-30-3
Molecular Formula:C₁₂H₁₃F₃N₂O₃
Molecular Weight:290.242
Hs Code.:

Synonyms:(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

Chemical Property:

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Technology Process of (S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

There total 3 articles about (S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 77001-77-5
C₁₂H₁₄F₃NO

: 131654-30-3
(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

Guidance literature:: With sulfuric acid; nitric acid; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.cclet.2020.10.038

Reference yield:

: 51-57-0,4298-16-2
S-methamphetamine hydrochloride

: 131654-30-3
(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sulfuric acid; potassium nitrate / dichloromethane / 20 °C / Inert atmosphere

With sulfuric acid; potassium nitrate; triethylamine; In dichloromethane;
DOI:10.1021/ja108807j

Reference yield:

: 537-46-2
Methamphetamin

: 131654-30-3
(S)-2,2,2-trifluoro-N-methyl-N-(1-(4-nitrophenyl)propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.5 h / 0 °C / Inert atmosphere

2: nitric acid; sulfuric acid / 1 h / 0 °C / Inert atmosphere

With sulfuric acid; nitric acid;
DOI:10.1016/j.cclet.2020.10.038