(E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester

Base Information

• Chemical Name: (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester
• CAS No.: 79333-63-4
• Molecular Formula: C₁₂H₁₉O₇P
• Molecular Weight: 306.252
• Mol file: 79333-63-4.mol

Synonyms:(E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester

Chemical Property of (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester

There total 5 articles about (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-2-[2-Methoxy-4,4,5,5-tetramethyl-2-(2,4,6-trimethyl-phenoxy)-2λ5-[1,3,2]dioxaphospholan-2-yl]-but-2-enedioic acid dimethyl ester (107906-19-4) → 2-methoxy-4,4,5,5-tetramethyl-[1,3,2]dioxaphospholane 2-oxide (7443-26-7) + 2,4,6-trimethylanisole (4028-66-4) + (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester (79333-63-4)

Guidance literature:

at 160 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)87318-X

Reference yield: 75.0%

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane (14812-60-3) + dimethyl acetylenedicarboxylate (762-42-5) + benzoic acid (65-85-0,8013-63-6) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + (Z)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester (79333-64-5) + (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester (79333-63-4)

Guidance literature:

In dichloromethane; at 20 ℃; Yields of byproduct given;

DOI:10.1016/S0040-4020(01)96522-6

Reference yield:

(E)-2-[2-Methoxy-4,4,5,5-tetramethyl-2-(4-nitro-phenoxy)-2λ5-[1,3,2]dioxaphospholan-2-yl]-but-2-enedioic acid dimethyl ester (107905-78-2) → para-methoxynitrobenzene (100-17-4) + (E)-2-(4,4,5,5-Tetramethyl-2-oxo-2λ5-[1,3,2]dioxaphospholan-2-yl)-but-2-enedioic acid dimethyl ester (79333-63-4)

Guidance literature:

With water; Yield given. Multistep reaction. Yields of byproduct given; 1.) 120 deg C, 3 min, 2.) acetone, 20 deg C, 30 min;

DOI:10.1016/S0040-4020(01)87318-X

upstream raw materials:

2-(2-Methoxy-4,4,5,5-tetramethyl-2λ⁵-[1,3,2]dioxaphospholan-2-ylidene)-3-(2,4,6-trimethyl-benzoyloxy)-succinic acid dimethyl ester

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane

dimethyl acetylenedicarboxylate

benzoic acid