6-Chloro-2-hydroxymethylpyridine hydrochloride

Base Information

• Chemical Name: 6-Chloro-2-hydroxymethylpyridine hydrochloride
• CAS No.: 83782-89-2
• Molecular Formula: C₆H₆ClNO*ClH
• Molecular Weight: 180.034
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60516571
• Mol file: 83782-89-2.mol

Synonyms:83782-89-2;6-chloro-2-hydroxymethylpyridine hydrochloride;(6-chloropyridin-2-yl)methanol hydrochloride;6-Chloro-2-hydroxymethyl pyridine hydrochloride;6-Chloro-2-(hydroxymethyl)pyridine Hydrochloride;(6-chloropyridin-2-yl)methanol;hydrochloride;MFCD08690070;6-Chloro-2-hydroxymethyl pyridine, HCl;6-Chloro-2-hydroxymethylpyridine HCl;2-Pyridinemethanol, 6-chloro-, hydrochloride;DTXSID60516571;AMY31347;CL0095;AKOS005257864;AC-7513;CS-W003547;DS-0649;SB52394;SY007659;6-CHLORO-2-HYDROXYMETHYLPYRIDINEHCL;6-(chloropyridin-2-yl)methanol hydrochloride;FT-0650471;(6-chloropyridin-2-yl) methanol hydrochloride;J-501671;(6-Chloropyridin-2-yl)methanol--hydrogen chloride (1/1)

Chemical Property of 6-Chloro-2-hydroxymethylpyridine hydrochloride

Chemical Property:

• Melting Point: 137-140℃
• PSA: 33.12000
• LogP: 2.02930
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 178.9904692
• Heavy Atom Count: 10
• Complexity: 89.1

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-2-hydroxymethylpyridineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)Cl)CO.Cl

Technology Process of 6-Chloro-2-hydroxymethylpyridine hydrochloride

There total 2 articles about 6-Chloro-2-hydroxymethylpyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-6-methylpyridine N-oxide (52313-59-4) → 2-(hydroxymethyl)-6-chloropyridine hydrochloride (83782-89-2)

Guidance literature:

With hydrogenchloride; acetic anhydride; Yield given. Multistep reaction; 1.) 120-130 deg C, 2.5 h, 2.) reflux, 2 h;

DOI:10.1021/jm00356a018

Reference yield:

6-chloro-2-picoline (18368-63-3) → 2-(hydroxymethyl)-6-chloropyridine hydrochloride (83782-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 30percent H₂O₂, acetic acid

2: 1.) acetic anhydride, 2.) 10percent hydrochloric acid / 1.) 120-130 deg C, 2.5 h, 2.) reflux, 2 h

With hydrogenchloride; dihydrogen peroxide; acetic anhydride; acetic acid;

DOI:10.1021/jm00356a018

Reference yield:

2-(hydroxymethyl)-6-chloropyridine hydrochloride (83782-89-2) → 2-<<(p-bromophenyl)thio>methyl>-6-chloropyridine (83782-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.5 h / Heating

2: 44 percent / sodium ethoxide / ethanol / Ambient temperature

With thionyl chloride; sodium ethanolate; In ethanol;

DOI:10.1021/jm00356a018

upstream raw materials:

2-Chloro-6-methylpyridine N-oxide

6-chloro-2-picoline

Downstream raw materials:

2-<<(p-bromophenyl)thio>methyl>-6-chloropyridine

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