{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

Base Information

Chemical Name:{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile
CAS No.:1140589-63-4
Molecular Formula:C₂₆H₂₈N₄O₆
Molecular Weight:492.532
Hs Code.:

Synonyms:{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

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Chemical Property of {[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

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Technology Process of {[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

There total 10 articles about {[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140589-62-3
1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-6-hydroxyquinazoline-2,4(1H,3H)-dione

: 590-17-0
cyanomethyl bromide

: 1140589-63-4
{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

Guidance literature:: 1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-6-hydroxyquinazoline-2,4(1H,3H)-dione; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

cyanomethyl bromide; In N,N-dimethyl-formamide; at 100 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1140590-85-7
1-(1-acetylpiperidin-4-yl)-6-(benzyloxy)-3-(3,4-dimethoxybenzyl)quinazoline-2,4(1H,3H)-dione

: 1140589-63-4
{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 0.25 h / 100 °C / Microwave irradiation

With ammonium formate; caesium carbonate; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1140589-63-4
{[1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl]oxy}acetonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 110 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / 1,2-dichloro-ethane / 80 °C / Microwave irradiation

3.1: sodium hydroxide; water / methanol / 3 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

4.3: 448 h / 20 °C

5.1: sodium hydroxide; water / dichloromethane / 110 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: triethylamine / dichloromethane / 0 - 20 °C

8.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation

9.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

9.2: 0.25 h / 100 °C / Microwave irradiation

With water; ammonium formate; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;