Technology Process of 1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-6-hydroxyquinazoline-2,4(1H,3H)-dione
There total 9 articles about 1-(1-acetylpiperidin-4-yl)-3-(3,4-dimethoxybenzyl)-6-hydroxyquinazoline-2,4(1H,3H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium formate;
palladium 10% on activated carbon;
In
ethanol;
at 80 ℃;
for 2h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / 110 °C / Microwave irradiation
2.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / 1,2-dichloro-ethane / 80 °C / Microwave irradiation
3.1: sodium hydroxide; water / methanol / 3 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C
4.2: 0.5 h / 20 °C
4.3: 448 h / 20 °C
5.1: sodium hydroxide; water / dichloromethane / 110 °C / Microwave irradiation
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.1: triethylamine / dichloromethane / 0 - 20 °C
8.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation
With
water; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine; sodium hydroxide / 1,2-dichloro-ethane / 80 °C / Microwave irradiation
2.1: sodium hydroxide; water / methanol / 3 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 0.5 h / 20 °C
3.3: 448 h / 20 °C
4.1: sodium hydroxide; water / dichloromethane / 110 °C / Microwave irradiation
5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
6.1: triethylamine / dichloromethane / 0 - 20 °C
7.1: ammonium formate / palladium 10% on activated carbon / ethanol / 2 h / 80 °C / Microwave irradiation
With
water; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
