4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine

Base Information

Chemical Name:4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine
CAS No.:306293-36-7
Molecular Formula:C28H37F3N4O
Molecular Weight:502.623
Hs Code.:
Mol file:306293-36-7.mol

Synonyms:(2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-methyl-4-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidin-1-yl)-methanone;

Suppliers and Price of 4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine

Chemical Property:

PSA：39.68000
LogP:5.29290

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine

There total 11 articles about 4-[1-(2,4-Dimethyl-3-pyridinylcarbonyl)-4-methyl-4-piperidinyl}-2(S)-methyl-1-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 55314-30-2
2,4-dimethylnicotinic acid

: 544704-12-3
2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine

: 306293-36-7
Sch 350581

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 24h;

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 306293-36-7
Sch 350581

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / 2M borane-methyl sulfide complex / (S)-2-methyl oxaborolidine / tetrahydrofuran / 0.25 h / cooling

2: 96 percent / Et₃N / CH₂Cl₂ / 1 h / cooling

3: 1.5 g / 2,2,6,6-tetramethylpiperidine / acetonitrile / 16 h / Heating

4: TFA / basification

5: 2.16 g / Ti(OiPr)4 / CH₂Cl₂; toluene / 44 h / 20 °C

6: 1.85 g / tetrahydrofuran; diethyl ether / 19 h / 20 °C / cooling

7: 90 percent / trifluoro acetic acid / CH₂Cl₂ / 2 h / 25 °C / basification

8: 1.1 g / EDCI; HOBt; diisopropyl ethyl amine / CH₂Cl₂ / 24 h / 25 °C

With 2,2,6,6-tetramethyl-piperidine; titanium(IV) isopropylate; dimethylsulfide borane complex; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2-methyl oxaborolidine; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; acetonitrile; 3: Sn2 displacement;
DOI:10.1021/jm0155401

Reference yield:

: 74879-18-8
(S)-2-methylpiperazine

: 306293-36-7
Sch 350581

Guidance literature:: Multi-step reaction with 7 steps

1: 1.5 g / 2,2,6,6-tetramethylpiperidine / acetonitrile / 16 h / Heating

2: TFA / basification

3: 2.16 g / Ti(OiPr)4 / CH₂Cl₂; toluene / 44 h / 20 °C

4: 1.85 g / tetrahydrofuran; diethyl ether / 19 h / 20 °C / cooling

5: 90 percent / trifluoro acetic acid / CH₂Cl₂ / 2 h / 25 °C / basification

6: 1.1 g / EDCI; HOBt; diisopropyl ethyl amine / CH₂Cl₂ / 24 h / 25 °C

With 2,2,6,6-tetramethyl-piperidine; titanium(IV) isopropylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; acetonitrile; 2: Sn2 displacement;
DOI:10.1021/jm0155401