ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

Base Information

• Chemical Name: ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate
• CAS No.: 1308815-04-4
• Molecular Formula: C₂₁H₂₁ClN₂O₅S
• Molecular Weight: 448.927
• Mol file: 1308815-04-4.mol

Synonyms:ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

Chemical Property of ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate

There total 9 articles about ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-chlorothiophene-2-carbonyl chloride (42518-98-9) + ethyl 1-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)cyclopropanecarboxylate (1308815-03-3) → ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate (1308815-04-4)

Guidance literature:

With pyridine; In dichloromethane; at 10 - 30 ℃; for 4h;

Reference yield:

ethyl 1-(4-aminophenyl)cyclopropanecarboxylate (1308814-99-4) → ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate (1308815-04-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 15 h / 80 °C

2: chloroform / 3 h / 65 °C

3: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

4: pyridine / dichloromethane / 4 h / 10 - 30 °C

With pyridine; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water;

Reference yield:

1-cyano-1-phenylcyclopropane (935-44-4) → ethyl 1-[4-(5-{[(5-chlorothiophene-2-carbonyl)amino]methyl}-2-oxo-oxazolidin-3-yl)phenyl]cyclopropanecarboxylate (1308815-04-4)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium nitrate; sulfuric acid / 0 - 20 °C

2: sulfuric acid / 10 h / 26 °C / Reflux

3: tin(II) chloride hydrate / ethyl acetate / 4 h / 25 - 75 °C

4: ethanol / 15 h / 80 °C

5: chloroform / 3 h / 65 °C

6: methylamine / water; tetrahydrofuran / 15 h / 10 - 30 °C

7: pyridine / dichloromethane / 4 h / 10 - 30 °C

With pyridine; sodium nitrate; tin(II) chloride hydrate; sulfuric acid; methylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; ethyl acetate;

upstream raw materials:

phenylacetonitrile

5-chlorothiophene-2-carbonyl chloride

ethyl 1-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)cyclopropanecarboxylate

1-cyano-1-phenylcyclopropane

Downstream raw materials:

5-chloro-N-((3-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide

N-((3-(4-(1-(bromomethyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)-5-chlorothiophene-2-carboxamide

5-chloro-N-((3-(4-(1-((dimethylamino)methyl)cyclopropyl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide