3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Base Information

Chemical Name:3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine
CAS No.:115678-28-9
Molecular Formula:C₃₁H₄₂N₂O₉
Molecular Weight:586.682
Hs Code.:

Synonyms:3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Chemical Property of 3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

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Technology Process of 3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

There total 10 articles about 3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

: 4755-77-5
Ethyl oxalyl chloride

: 112446-08-9,114030-15-8,115511-18-7,137120-99-1
2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>-7,9,10-trimethoxy-8,11-dimethyl-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

: 115678-28-9
3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.416667h;
DOI:10.1021/jo00253a022

Reference yield:

: 113479-98-4
(Z)-4-benzyl-1-<(isopropyloxy)carbonyl>-6-<2,4,5-trimethoxy-3-methylphenyl)methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

: 115678-28-9
3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

2: 14 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating

3: H₂ / 20percent Pd/C / ethanol / 24 h / 80 °C / 3040 Torr

4: 74.4 percent / triethylamine / CH₂Cl₂ / 0.42 h / 0 °C

With lithium aluminium tetrahydride; formic acid; lithium tri(t-butoxy)aluminum hydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00253a022

Reference yield:

: 113461-80-6
(Z)-4-benzyl-6-<(2,4,5-trimethoxy-3-methylphenyl)-methyl>-3-<(2,4,5-trimethoxy-3-methylphenyl)methylene>-2,5-piperazinedione

: 115678-28-9
3-<2-<(2,4,5-trimethoxy-3-methylphenyl)methyl>>-7,9,10-trimetoxy-8,11-dimethyl-3-(ethoxyoxalyl)-(1α,2α,5α)-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 25 °C

2: 1.) lithium tri-tert-butoxyaluminium hydride, 2.) HCOOH / 1.) THF, 1 h, 2.) 60 deg C, 1 h

3: 14 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating

4: H₂ / 20percent Pd/C / ethanol / 24 h / 80 °C / 3040 Torr

5: 74.4 percent / triethylamine / CH₂Cl₂ / 0.42 h / 0 °C

With dmap; lithium aluminium tetrahydride; formic acid; lithium tri(t-butoxy)aluminum hydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00253a022