2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester

Base Information

• Chemical Name: 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester
• CAS No.: 852068-73-6
• Molecular Formula: C₂₀H₂₂N₂O₃
• Molecular Weight: 338.406
• Mol file: 852068-73-6.mol

Synonyms:2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester

Chemical Property of 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester

There total 1 articles about 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl-2-[4-(2-oxoimidazolidin-1-yl)phenyl]propanoate (492445-82-6) + benzyl bromide (100-39-0) → 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester (852068-73-6)

Guidance literature:

methyl-2-[4-(2-oxoimidazolidin-1-yl)phenyl]propanoate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm0408870

Reference yield:

2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester (852068-73-6) → 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid (852068-74-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm0408870

Reference yield:

2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester (852068-73-6) → 2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-N-(5-cyclopropyl-1H-pyrazol-3-yl)-propionamide

Guidance literature:

Multi-step reaction with 3 steps

1.1: 180 mg / aq. LiOH / tetrahydrofuran / 3 h / 20 °C

2.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

2.2: CH₂Cl₂; dimethylformamide / 0 - 20 °C

3.1: trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

With lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0408870

upstream raw materials:

methyl-2-[4-(2-oxoimidazolidin-1-yl)phenyl]propanoate

benzyl bromide

Downstream raw materials:

2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid