2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid

Base Information

• Chemical Name: 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid
• CAS No.: 852068-74-7
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 852068-74-7.mol

Synonyms:2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid

Chemical Property of 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid

There total 3 articles about 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester (852068-73-6) → 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid (852068-74-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm0408870

Reference yield:

methyl-2-[4-(2-oxoimidazolidin-1-yl)phenyl]propanoate (492445-82-6) → 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid (852068-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: dimethylformamide / 2 h / 0 - 20 °C

2.1: 180 mg / aq. LiOH / tetrahydrofuran / 3 h / 20 °C

With lithium hydroxide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0408870

Reference yield:

benzyl bromide (100-39-0) → 2-[4-(3-benzyl-2-oxoimidazolidin-1-yl)phenyl]propanoic acid (852068-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: dimethylformamide / 2 h / 0 - 20 °C

2.1: 180 mg / aq. LiOH / tetrahydrofuran / 3 h / 20 °C

With lithium hydroxide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm0408870

upstream raw materials:

2-[4-(3-benzyl-2-oxo-imidazolidin-1-yl)-phenyl]-propionic acid methyl ester

methyl-2-[4-(2-oxoimidazolidin-1-yl)phenyl]propanoate

benzyl bromide