2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

Base Information

Chemical Name:2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine
CAS No.:1415354-06-1
Molecular Formula:C₂₈H₃₈N₂O₅
Molecular Weight:482.62
Hs Code.:

Synonyms:2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

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Chemical Property of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

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Technology Process of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

There total 6 articles about 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.4%

: 1415354-04-9
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methylquinolin-5-amine

: 78-84-2
isobutyraldehyde

: 1415354-06-1
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 132118-31-1
2-chloro-8-methoxy-3-methylquinoline

: 1415354-06-1
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1.5 h / Reflux

3.1: ammonium chloride; iron / water; ethanol / 1 h / Reflux

4.1: triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

5.2: 1 h / 40 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; iron; sodium hydride; potassium carbonate; ammonium chloride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 1415353-99-9
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methyl-5-nitroquinoline

: 1415354-06-1
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-N-(2-methoxyethyl)-3-methyl-N-(2-methylpropyl)quinolin-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / water; ethanol / 1 h / Reflux

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

3.2: 1 h / 40 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; iron; sodium hydride; ammonium chloride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028