L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

Base Information

Chemical Name:L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine
CAS No.:49863-06-1
Molecular Formula:C₃₆H₄₃N₁₁O₉
Molecular Weight:773.806
Hs Code.:

Synonyms:L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

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Technology Process of L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

There total 9 articles about L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10285-64-0
N^α-tert-butoxycarbonylseryltyrosine methyl ester

: 49863-06-1
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

Guidance literature:: Multi-step reaction with 6 steps

1: 1n NaOH, 1n HCl, HOBt hydrate, DCC / 1) 1h acetone, 2) -10deg C, DMF, 3) 18h to RT

2: 90 percent / 11.8n HCl / methanol

3: 82 percent / HOBt hydrate, pentachlorophenol, triethylamine / dimethylformamide / 19 h / Ambient temperature

4: 94 percent / 7n HCl / methanol / 0.08 h / Ambient temperature

5: 1) 9.2n HCl, isoamyl nitrite, 2) Et₃N / 1) DMF, THF, 30 min, -47 deg C, 2) 48h, -5 deg C

6: 99percent hydrazine hydrate / 1) -20 deg C, Et₃N, THF, 2) 48h to -5deg C, DMF 3) 20h to -5deg C

With hydrogenchloride; sodium hydroxide; Pentachlorophenol; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 49863-06-1
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / 1-hydroxybenzotriazol hydrate, N-methylmorpholine, DCC / tetrahydrofuran; CH₂Cl₂ / 1) 30 min, -5 deg C, 2) 20h, RT

2: 1n NaOH, 1n HCl, HOBt hydrate, DCC / 1) 1h acetone, 2) -10deg C, DMF, 3) 18h to RT

3: 90 percent / 11.8n HCl / methanol

4: 82 percent / HOBt hydrate, pentachlorophenol, triethylamine / dimethylformamide / 19 h / Ambient temperature

5: 94 percent / 7n HCl / methanol / 0.08 h / Ambient temperature

6: 1) 9.2n HCl, isoamyl nitrite, 2) Et₃N / 1) DMF, THF, 30 min, -47 deg C, 2) 48h, -5 deg C

7: 99percent hydrazine hydrate / 1) -20 deg C, Et₃N, THF, 2) 48h to -5deg C, DMF 3) 20h to -5deg C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; Pentachlorophenol; benzotriazol-1-ol; hydrazine hydrate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; isopentyl nitrite; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 15160-31-3
(tert-butyloxycarbonyl)-l-tryptophan p-nitrophenyl ester

: 49863-06-1
L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / HOBt hydrate, pentachlorophenol, triethylamine / dimethylformamide / 19 h / Ambient temperature

2: 94 percent / 7n HCl / methanol / 0.08 h / Ambient temperature

3: 1) 9.2n HCl, isoamyl nitrite, 2) Et₃N / 1) DMF, THF, 30 min, -47 deg C, 2) 48h, -5 deg C

4: 99percent hydrazine hydrate / 1) -20 deg C, Et₃N, THF, 2) 48h to -5deg C, DMF 3) 20h to -5deg C

With hydrogenchloride; Pentachlorophenol; benzotriazol-1-ol; hydrazine hydrate; triethylamine; isopentyl nitrite; In methanol; N,N-dimethyl-formamide;