BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

Base Information

Chemical Name:BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll
CAS No.:363602-36-2
Molecular Formula:C₄₈H₅₀N₄O₁₁
Molecular Weight:858.945
Hs Code.:

Synonyms:BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

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Chemical Property of BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

Chemical Property:

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Technology Process of BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

There total 8 articles about BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 363602-36-2
BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / PyCloP; DIEA / CH₂Cl₂

2: DMDPd; morpholine / tetrahydrofuran / 0.5 h / 20 °C

3: PyCloP; DIEA / CH₂Cl₂

With morpholine; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016158l

Reference yield:

: 99-31-0
5-aminoisophthalic acid

: 363602-36-2
BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

Guidance literature:: Multi-step reaction with 7 steps

1.1: 98 percent / sodium hydroxide / H₂O; dioxane / 0 - 20 °C

2.1: NaHCO₃ / dimethylformamide

2.2: 34 percent / dimethylformamide / 24 h

3.1: 81 percent / NaHCO₃ / dimethylformamide / 48 h / 20 °C

4.1: TFA / CH₂Cl₂ / 1.5 h / 0 - 5 °C

5.1: 99 percent / PyCloP; DIEA / CH₂Cl₂

6.1: DMDPd; morpholine / tetrahydrofuran / 0.5 h / 20 °C

7.1: PyCloP; DIEA / CH₂Cl₂

With morpholine; sodium hydroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol016158l

Reference yield:

: 178446-63-4
5-[(tert-butyloxycarbonyl)amino]-isophthalic acid

: 363602-36-2
BOC-[(L)-Pro-(5-aminoisophthalic acid)-(OBn)]2-OAll

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaHCO₃ / dimethylformamide

1.2: 34 percent / dimethylformamide / 24 h

2.1: 81 percent / NaHCO₃ / dimethylformamide / 48 h / 20 °C

3.1: TFA / CH₂Cl₂ / 1.5 h / 0 - 5 °C

4.1: 99 percent / PyCloP; DIEA / CH₂Cl₂

5.1: DMDPd; morpholine / tetrahydrofuran / 0.5 h / 20 °C

6.1: PyCloP; DIEA / CH₂Cl₂

With morpholine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; chlorotri(pyrrolidin-1-yl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016158l