Technology Process of 3,17β-dibenzyloxy-11β-(2-methoxyethyl)estra-1,3,5(10)-triene
There total 2 articles about 3,17β-dibenzyloxy-11β-(2-methoxyethyl)estra-1,3,5(10)-triene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether);
With
potassium hydride;
In
toluene;
at 20 ℃;
for 0.5h;
methyl iodide;
In
toluene;
at 20 ℃;
for 48h;
DOI:10.1021/jm049352x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: LiBH4; catecholborane / tetrahydrofuran / 21 h / 20 °C
1.2: 80 percent / NaOH; aq. H2O2 / ethanol / 6 h / 20 °C
2.1: KH / toluene / 0.5 h / 20 °C
2.2: 100 percent / toluene / 48 h / 20 °C
With
lithium borohydride; potassium hydride; benzo[1,3,2]dioxaborole;
In
tetrahydrofuran; toluene;
DOI:10.1021/jm049352x