(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

Base Information

Chemical Name:(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine
CAS No.:1613148-17-6
Molecular Formula:C₃₃H₃₈Cl₂FN₅O₇
Molecular Weight:706.598
Hs Code.:

(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

Synonyms:(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

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Chemical Property of (R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

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Technology Process of (R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

There total 10 articles about (R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877397-70-1
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine

: 1613148-17-6
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

: 1613148-18-7
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; iron / ethanol / 2.58 h / 90 °C

2.1: N-Bromosuccinimide / acetonitrile / 1.33 h / 0 °C

3.1: triethylamine; dmap / tetrahydrofuran / 70 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 5 h / 80 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5.2: 3 h / 110 °C

5.3: 12 h / 85 °C / Inert atmosphere

With hydrogenchloride; dmap; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; iron; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 877399-48-9
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

: 949922-48-9
6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine

: 1613148-17-6
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

: 1613148-18-7
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)pyridin-2-amine

Guidance literature:: 6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

With trichlorophosphate; at 110 ℃; for 3h;

(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; water; at 85 ℃; for 12h; Overall yield = 46 %; Overall yield = 0.42 g; Inert atmosphere;

Reference yield:

: 254-86-4
pyrido[3,4-b]pyrazine

: 1613148-17-6
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine

: 1613148-18-7
(R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -25 °C

1.2: 1 h

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.2: 3 h / 110 °C

3.3: 12 h / 85 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;