254-86-4

Basic information

• Product Name: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)
• Synonyms: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI);pyridino[3,4-b]pyrazine
• CAS NO: 254-86-4
• Molecular Formula: C₇H₅N₃
• Molecular Weight: 131.137
• Product Categories: QUINOXALINE
• Mol File: 254-86-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 97 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 273.5°C at 760 mmHg
• Flash Point: 128.7°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.00956mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 3.60±0.10(Predicted)
• CAS DataBase Reference: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)(254-86-4)
• EPA Substance Registry System: Pyrido[3,4-b]pyrazine (6CI,7CI,8CI,9CI)(254-86-4)

Safety Data

• Hazardous Substances Data: 254-86-4(Hazardous Substances Data)

Usage

General Description

Pyrido[3,4-b]pyrazine is a heterocyclic chemical compound, listed under CAS Registry Number 1214-72-4. It is one of the isotopes of the basic pyrazine ring structure, which belongs to the class of organic compounds known as pyrido[3,4-b]pyrazines. As an isotope, it has specific physical and chemical properties, although specific information regarding its properties, applications or production is not widely available in existing literature. Generally, pyrazines and their derivatives are known for their functions in a variety of chemical reactions and are utilized in several industries due to their characteristic aromatic and nitrogen-containing properties. As with all chemical compounds, handling of Pyrido[3,4-b]pyrazine should be done with care to maintain safety and avoid adverse reactions.

InChI:InChI=1/C7H5N3/c1-2-8-5-7-6(1)9-3-4-10-7/h1-5H

Upstream product

• 54-96-6 3,4-diaminopyridine 
• 131543-46-9 Glyoxal 
• 517-21-5 glyoxal sodium bisulfite 

Downstream Products

• 1613148-14-3 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine 
• 1613148-15-4 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)pyridin-2-amine 
• 1613148-17-6 (R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-yl)pyridin-2-amine 
• 1613148-18-7 (R)-N,N-bis(tert-butoxycarbonyl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-yl)pyridin-2-amine 
• 949922-49-0 2-chloro-6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine 
• 1613148-16-5 3-chloro-6-(ethoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine 
• 1133853-73-2 (R)-N-(4-fluorophenyl)-5-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxamide 
• 1133853-72-1 5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine 
• 1133854-27-9 (R)-5-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine 
• 1133853-70-9 ethyl 5-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate 
• 1133853-67-4 ethyl 5-(4-(trifluoromethyl)phenyl)pyrido[3,4-b]pyrazine-6(5H)-carboxylate 
• 929074-45-3 8-bromopyrido[3,4-b]pyrazine 
• 1133854-32-6 benzyl 8-(4-(trifluoromethyl)phenyl)-1,7-naphthyridine-7(8H)-carboxylate 
• 1133854-33-7 ethyl 8-(4-fluorophenyl)-1,7-naphthyridine-7(8H)-carboxylate 

Relevant articles and documents

Annelated Pyridine Bases for the Selective Acylation of 1,2-Diols

A set of 24 annelated derivatives of 4-diaminopyridine (DMAP) has been synthesized and tested with respect to its catalytic potential in the regioselective acylation of 1,2-diol substrates. The Lewis basicities of the catalysts as quantified through quantum chemical calculations vary due to inductive substituent effects and intramolecular stacking interactions between side chain π-systems and the pyridinium core ring system. The primary over secondary hydroxyl group selectivities in catalytic acylations of 1,2-diol substrates depend on the size and the steric demand of the Lewis base and the anhydride reagent.

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Annelated pyridines as highly nucleophilic and Lewis basic catalysts for acylation reactions

New heterocyclic derivatives of 9-azajulolidine have been synthesized and characterized with respect to their nucleophilicity and Lewis basicity. The Lewis basicity of these bases as quantified through their theoretically calculated methyl-cation affinities correlate well with the experimentally measured reaction rates for addition to benzhydryl cations. All newly synthesized pyridines show exceptional catalytic activities in benchmark acylation reactions, which correlate only poorly with Lewis basicity or nucleophilicity parameters. A combination of Lewis basicity with charge and geometric parameters in the framework of a three-component quantitative structure-activity relationship (QSAR) model is, however, highly predictive. Copyright