3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

Base Information

Chemical Name:3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid
CAS No.:1617501-32-2
Molecular Formula:C₁₉H₂₆ClNO₅
Molecular Weight:383.872
Hs Code.:

Synonyms:3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

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Chemical Property of 3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

Chemical Property:

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Technology Process of 3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

There total 5 articles about 3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1617501-33-3
methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

: 1617501-32-2
3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

Guidance literature:: With methanol; sodium hydroxide; for 2h; Reflux;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-32-2
3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 55 °C / Sealed tube; Microwave irradiation; Inert atmosphere

5.1: methanol; sodium hydroxide / 2 h / Reflux

With methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1549275-48-0
5-chloro-3-iodo-2-methylbenzoic acid

: 1617501-32-2
3-(((1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

2.1: thionyl chloride / 0.25 h / Cooling with ice

2.2: 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 55 °C / Sealed tube; Microwave irradiation; Inert atmosphere

4.1: methanol; sodium hydroxide / 2 h / Reflux

With methanol; copper(l) iodide; 8-quinolinol; thionyl chloride; di-isopropyl azodicarboxylate; triphenylphosphine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;