methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

Base Information

Chemical Name:methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate
CAS No.:1617501-33-3
Molecular Formula:C₂₀H₂₈ClNO₅
Molecular Weight:397.899
Hs Code.:

Synonyms:methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

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Chemical Property of methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

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Technology Process of methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

There total 4 articles about methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 167081-25-6
cis-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester

: methyl 5-chloro-3-hydroxy-2-methylbenzoate

: 1617501-33-3
methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 55 ℃; for 1h; Sealed tube; Microwave irradiation; Inert atmosphere;

Reference yield: 23.57%

: 1007306-61-7
(1S,4S)-4-((tert-butoxycarbonyl)amino)-cyclohexyl methanesulfonate

: methyl 5-chloro-3-hydroxy-2-methylbenzoate

: 1617501-33-3
methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 65 ℃; for 72h; Inert atmosphere;

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 1617501-33-3
methyl 3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)oxy)-5-chloro-2-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione / 2 h

2.1: copper(l) iodide; 8-quinolinol; potassium hydroxide / tert-butyl alcohol; dimethyl sulfoxide; water / 24 h / 100 °C / Inert atmosphere

3.1: thionyl chloride / 0.25 h / Cooling with ice

3.2: 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 55 °C / Sealed tube; Microwave irradiation; Inert atmosphere

With copper(l) iodide; 8-quinolinol; thionyl chloride; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; di-isopropyl azodicarboxylate; sulfuric acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;