3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

Base Information

Chemical Name:3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile
CAS No.:1241916-12-0
Molecular Formula:C₂₁H₁₇FN₆
Molecular Weight:372.405
Hs Code.:

Synonyms:3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

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Chemical Property of 3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

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Technology Process of 3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

There total 6 articles about 3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 1241914-71-5
(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone

: 1241916-12-0
3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

(4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)methanone; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 70 ℃;

Reference yield:

: 34632-69-4
ethyl 4-chloro-quinazoline-2-carboxylate

: 1241916-12-0
3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran

3: acetic acid; sodium hydride / Pd-C / ethanol; tetrahydrofuran; mineral oil

With hydrogenchloride; sodium hydride; acetic acid; Pd-C; In tetrahydrofuran; ethanol; mineral oil;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1241916-12-0
3-(4-fluorophenyl)-3-(4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-2-yl)propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / tetrahydrofuran

2: DIEA / N,N-dimethyl-formamide; water

3: acetic acid; sodium hydride / Pd-C / ethanol; tetrahydrofuran; mineral oil

With hydrogenchloride; sodium hydride; DIEA; acetic acid; Pd-C; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;