(6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid

Base Information

• Chemical Name: (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid
• CAS No.: 33879-91-3
• Molecular Formula: C₂₄H₁₃NO₅
• Molecular Weight: 395.371
• Mol file: 33879-91-3.mol

Synonyms:(6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid

Chemical Property of (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid

There total 12 articles about (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(6,11-Dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carbonyl)-benzoic acid methyl ester (33879-92-4) → (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid (33879-91-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Heating;

Reference yield: 68.0%

pyridine (110-86-1) + 2,3-Dichloro-1,4-naphthoquinone (117-80-6) + 1H-indene-1,3(2H)-dione (606-23-5) → (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid (33879-91-3)

Guidance literature:

2,3-Dichloro-1,4-naphthoquinone; 1H-indene-1,3(2H)-dione; In acetonitrile; for 1h; Reflux;

With dihydrogen peroxide; In water; acetonitrile; for 0.25h;

pyridine; In water; acetonitrile; Reflux;

DOI:10.1007/s10895-015-1687-x

Reference yield:

2,3-Dichloro-1,4-naphthoquinone (117-80-6) → (6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonylbenzoic acid (33879-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 percent / 4 h / Heating

2: potassium hydroxide / aq. ethanol / 2 h

With potassium hydroxide; In ethanol;

upstream raw materials:

pyridine

2,3-Dichloro-1,4-naphthoquinone

1H-indene-1,3(2H)-dione

ethanol

Downstream raw materials:

ethyl 2-<(6,11-dihydro-6,11-dioxonaphth<2,3-b>indolizin-12-yl)carbonyl>benzoate