1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene

Base Information

• Chemical Name: 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene
• CAS No.: 142397-82-8
• Molecular Formula: C₃₂H₄₂O₆
• Molecular Weight: 522.682
• Mol file: 142397-82-8.mol

Synonyms:1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene

Chemical Property of 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene

There total 7 articles about 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,3,5,6-tetramethoxy-1,4-bis<4-(2-methoxycarbonylphenyl)butyl>benzene (142397-77-1) → 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene (142397-82-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Heating;

Reference yield:

1,2,4,5-tetramethoxybenzene (2441-46-5) → 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene (142397-82-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) n-butyllithium, 2.) iodine / 1.) THF, diethylether, hexane, 20 deg C, 4 h, 2.) THF, 0 deg C

2: 89 percent / triethylamine / palladium(II) acetate, tri-ortho-tolylphosphane / acetonitrile / 70 h / 70 °C

3: 85 percent / diisobutylaluminium hydride / CH₂Cl₂ / -30 - 0 °C

4: 90 percent / barium manganate(VI) / CH₂Cl₂ / 2.5 h / Heating

5: 1.) sodium methanolate / 1.) methanol, 70 deg C, 30 min, 2.) THF, 70 deg C, 2 h

6: 93 percent / hydrogen / 10 percent Pd/C / ethyl acetate; methanol / 5 h / 80 °C

7: 88 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; n-butyllithium; barium manganate; hydrogen; iodine; sodium methylate; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

1,4-diiodo-2,3,5,6-tetramethoxybenzene (54812-45-2) → 1,4-bis<4-(2-hydroxymethylphenyl)butyl>-2,3,5,6-tetramethoxybenzene (142397-82-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 89 percent / triethylamine / palladium(II) acetate, tri-ortho-tolylphosphane / acetonitrile / 70 h / 70 °C

2: 85 percent / diisobutylaluminium hydride / CH₂Cl₂ / -30 - 0 °C

3: 90 percent / barium manganate(VI) / CH₂Cl₂ / 2.5 h / Heating

4: 1.) sodium methanolate / 1.) methanol, 70 deg C, 30 min, 2.) THF, 70 deg C, 2 h

5: 93 percent / hydrogen / 10 percent Pd/C / ethyl acetate; methanol / 5 h / 80 °C

6: 88 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Heating

With lithium aluminium tetrahydride; barium manganate; hydrogen; sodium methylate; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

upstream raw materials:

2,3,5,6-tetramethoxy-1,4-bis<4-(2-methoxycarbonylphenyl)butyl>benzene

1,2,4,5-tetramethoxybenzene

1,4-diiodo-2,3,5,6-tetramethoxybenzene

(E,E)-1,4-bis(2-formylethenyl)-2,3,5,6-tetramethoxybenzene

Downstream raw materials:

1,4-bis<4-(2-formylphenyl)butyl>-2,3,5,6-tetramethoxybenzene