N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

Base Information

Chemical Name:N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide
CAS No.:1373545-22-2
Molecular Formula:C₂₄H₂₂F₄N₂O₂S
Molecular Weight:478.51
Hs Code.:

Synonyms:N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

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Chemical Property of N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

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Technology Process of N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

There total 5 articles about N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 701-27-9
3-fluorobenzene-1-sulfonyl chloride

: 1373546-81-6
2-(4,4-dimethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-yl)aniline

: 1373545-22-2
N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1373545-22-2
N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / Reflux

2: boron trifluoride diethyl etherate / acetonitrile / 90 °C / sealed tube; Cooling with ice

3: ammonium chloride; iron / ethanol; water / 3 h / Inert atmosphere; Reflux

4: pyridine / dichloromethane / 3 h / 20 °C / Cooling with ice

With pyridine; iron; ammonium chloride; boron trifluoride diethyl etherate; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 1373545-22-2
N-[2-(4,4-dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenyl]-3-fluoro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 3 h / Reflux

2: boron trifluoride diethyl etherate / acetonitrile / 90 °C / sealed tube; Cooling with ice

3: ammonium chloride; iron / ethanol; water / 3 h / Inert atmosphere; Reflux

4: pyridine / dichloromethane / 3 h / 20 °C / Cooling with ice

With pyridine; iron; ammonium chloride; boron trifluoride diethyl etherate; In ethanol; dichloromethane; water; acetonitrile;