2-(3-chlorophenyl)-7-azaspiro[3.5]nonane

Base Information

• Chemical Name: 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane
• CAS No.: 1225276-16-3
• Molecular Formula: C₁₄H₁₈ClN
• Molecular Weight: 235.757
• Mol file: 1225276-16-3.mol

Synonyms:2-(3-chlorophenyl)-7-azaspiro[3.5]nonane

Chemical Property of 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane

There total 5 articles about 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (1225276-15-2) → 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane (1225276-16-3)

Guidance literature:

tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate; With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester (240401-28-9) → 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane (1225276-16-3)

Guidance literature:

Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran

2: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

3: hydrogenchloride / 1,4-dioxane; dichloromethane

With nickel(II) iodide; hydrogenchloride; carbon tetrabromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.048

Reference yield:

tert-butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate (1225276-07-2) → 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane (1225276-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel(II) iodide; lithium hexamethyldisilazane / isopropyl alcohol

2: hydrogenchloride / 1,4-dioxane; dichloromethane

With nickel(II) iodide; hydrogenchloride; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; isopropyl alcohol; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.08.048

upstream raw materials:

tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester

tert-butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate