tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate
• CAS No.: 1225276-15-2
• Molecular Formula: C₁₉H₂₆ClNO₃
• Molecular Weight: 351.873
• Mol file: 1225276-15-2.mol

Synonyms:tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property of tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate

There total 1 articles about tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chlorophenyl)magnesium bromide (36229-42-2) + tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (1225276-15-2)

Guidance literature:

(3-chlorophenyl)magnesium bromide; tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate; In tetrahydrofuran; at 0 ℃; for 3h;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate (1225276-15-2) → 2-(3-chlorophenyl)-7-azaspiro[3.5]nonane (1225276-16-3)

Guidance literature:

tert-butyl 2-(3-chlorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate; With triethylsilane; boron trifluoride diethyl etherate; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In ethyl acetate;

upstream raw materials:

(3-chlorophenyl)magnesium bromide

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

Downstream raw materials:

2-(3-chlorophenyl)-7-azaspiro[3.5]nonane