(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

Base Information

Chemical Name:(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline
CAS No.:795275-78-4
Molecular Formula:C₂₀H₂₉NO₂S
Molecular Weight:347.522
Hs Code.:

Synonyms:(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

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Chemical Property of (4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

Chemical Property:

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Technology Process of (4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

There total 3 articles about (4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 590-14-7
1-bromo-1-propene

: 795275-73-9
N-[(1R,2S,3R)-2-allyl-3-methylcyclohexyl]-4-toluenesulfonamide

: 795275-78-4
(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

Guidance literature:: With palladium(III) acetate; sodium carbonate; tris-(o-tolyl)phosphine; tetrabutyl-ammonium chloride; In acetonitrile; at 86 ℃; for 68h;
DOI:10.1016/j.tet.2004.06.148

Reference yield:

: 795275-76-2
2-[(1R,2S,3R)-2-allyl-3-methylcyclohexyl]-1H-isoindole-1,3(2H)-dione

: 795275-78-4
(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate; 1-hexene / ethanol / Heating

2: 95 percent / Et₃N / CH₂Cl₂ / 60 h / 20 °C

3: Pd(OAc)3; P(o-Tol)3; Na₂CO₃ / n-Bu₄NCl / acetonitrile / 68 h / 86 °C

With 1-hexene; palladium(III) acetate; sodium carbonate; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; tetrabutyl-ammonium chloride; In ethanol; dichloromethane; acetonitrile; 3: Heck reaction;
DOI:10.1016/j.tet.2004.06.148

Reference yield:

: 795275-77-3
(1R,2S,3R)-2-allyl-3-methylcyclohexylamine

: 795275-78-4
(4aS,5R,8aR)-5-Methyl-2-((E)-propenyl)-1-(toluene-4-sulfonyl)-decahydro-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 60 h / 20 °C

2: Pd(OAc)3; P(o-Tol)3; Na₂CO₃ / n-Bu₄NCl / acetonitrile / 68 h / 86 °C

With palladium(III) acetate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; tetrabutyl-ammonium chloride; In dichloromethane; acetonitrile; 2: Heck reaction;
DOI:10.1016/j.tet.2004.06.148