5-(2-Bromophenyl)-picolinic acid

Base Information

• Chemical Name: 5-(2-Bromophenyl)-picolinic acid
• CAS No.: 87789-85-3
• Molecular Formula: C₁₂H₈ClNO₂
• Molecular Weight: 233.654
• Hs Code.: 2933399090
• Mol file: 87789-85-3.mol

Synonyms:5-(4-Chlorophenyl)-2-pyridinecarboxylicacid

Chemical Property of 5-(2-Bromophenyl)-picolinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 3.20930
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

5-(4-Chlorophenyl)picolinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-Bromophenyl)-picolinic acid

There total 2 articles about 5-(2-Bromophenyl)-picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

→ 5-(4-chlorophenyl)picolinic acid (87789-85-3)

Guidance literature:

Reference yield:

5-bromoisonicotinic acid (30766-11-1) + 4-Chlorophenylboronic acid (1679-18-1) → 5-(4-chlorophenyl)picolinic acid (87789-85-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2016.01.001

Reference yield:

5-(4-chlorophenyl)picolinic acid (87789-85-3) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl)-5-(4-chlorophenyl)picolinamide

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmc.2016.01.001

upstream raw materials:

5-bromoisonicotinic acid

4-Chlorophenylboronic acid

Refernces

• 1、 Wang, Min,Wu, Chunjiang,Xu, Shan,Zhu, Yan,Li, Wei,Zheng, Pengwu,Zhu, Wufu. "Synthesis, biological evaluation and docking studies of sorafenib derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides". . p. 176 - 185. Retrieved 2017/03/08.
• 2、 -. "ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA". Page/Page column 54. . Retrieved 2008/06/13.