3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

Base Information

Chemical Name:3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine
CAS No.:1350852-18-4
Molecular Formula:C₃₀H₄₈N₂O₇Si₂
Molecular Weight:604.891
Hs Code.:

Synonyms:3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

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Chemical Property of 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

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Technology Process of 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

There total 5 articles about 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 130983-87-8
1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione

: 1350852-18-4
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

Guidance literature:: 1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione; With pyridine; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; In toluene; acetonitrile; at 20 ℃; for 4h;

2.6-dimethylphenol; With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2018.12.005

Reference yield:

: 576-26-1,25134-01-4
2.6-dimethylphenol

: C₃₇H₆₂N₂O₉SSi₂

: 1350852-18-4
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1039/c1cc14339e

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 1350852-18-4
3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-O-(2,6-dimethylphenyl)-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h / 20 °C

2: tetrabutylammomium bromide; sodium carbonate / dichloromethane; water / 3 h / 20 °C

3: 1,4-diaza-bicyclo[2.2.2]octane; triethylamine / acetonitrile / 1 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; tetrabutylammomium bromide; sodium carbonate; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1039/c1cc14339e