3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene

Base Information

• Chemical Name: 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene
• CAS No.: 156810-89-8
• Molecular Formula: C₁₉H₁₄Cl₂N₂O₃
• Molecular Weight: 389.238

Synonyms:3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene

Chemical Property of 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene

Chemical Property:

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Technology Process of 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene

There total 2 articles about 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(3,5-dichlorophenyl)-3-methylenepyrrolidine-2,5-dione (26958-82-7) + N-hydroxy-4-methylbenzenecarboximidoyl chloride (36288-37-6) → 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene (156810-89-8)

Guidance literature:

With triethylamine; In diethyl ether; Ambient temperature;

DOI:10.1007/BF00811316

Reference yield:

p-methylbenzaldehyde oxime (3235-02-7,3717-15-5,3717-16-6,140461-26-3,140461-27-4) → 3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene (156810-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorinating agent / CHCl₃

2: 83 percent / Et₃N / diethyl ether / Ambient temperature

With chlorinating agent; triethylamine; In diethyl ether; chloroform;

DOI:10.1007/BF00811316

Reference yield: 70.0%

3-(4-methylphenyl)-7-(3,5-dichlorophenyl)-6,8-dioxo-1-oxa-2,7-diazaspiro<4,4>-non-2-ene (156810-89-8) → 3-(4-methylphenyl)-5-hydroxymethyl-5-(3,5-dichlorophenylcarbamoylmethyl)-2-isoxazoline

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h;

DOI:10.1007/BF00811316

upstream raw materials:

1-(3,5-dichlorophenyl)-3-methylenepyrrolidine-2,5-dione

N-hydroxy-4-methylbenzenecarboximidoyl chloride

p-methylbenzaldehyde oxime

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