N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

Base Information

Chemical Name:N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester
CAS No.:869307-75-5
Molecular Formula:C₁₉H₁₈N₄O₅
Molecular Weight:382.376
Hs Code.:

Synonyms:N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

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Chemical Property of N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

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Technology Process of N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

There total 1 articles about N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 42918-86-5,1145-79-5,2900-20-1,20395-87-3
(S)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: 28230-32-2
3-hydroxy-3,4-dihydrobenzotriazine-4-one

: 869307-75-5
N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm0500830

Reference yield: 100.0%

: 869307-75-5
N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

: 5227-53-2
(2R/S)-azepinecarboxylic acid

: 869307-76-6
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2R/S)-perhydroazepinecarboxylic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 120h;
DOI:10.1021/jm0500830

Reference yield:

: 869307-75-5
N-benzyloxycarbonyl-(2S)-aminobutyric acid 3,4-dihydro-4-oxo-1,2,3-benzotriazine ester

: 869307-77-7
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2R/S)-perhydroazepinecarboxylic acid n-butylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / Et₃N / dimethylformamide / 120 h / 20 °C

2.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

2.2: 52 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0500830