methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Base Information

Chemical Name:methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate
CAS No.:1403934-24-6
Molecular Formula:C₂₉H₄₂N₄O₃
Molecular Weight:494.677
Hs Code.:

Synonyms:methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Suppliers and Price of methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

There total 5 articles about methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1403934-22-4
methyl (3R,5S,αR)-3-[N-(3′-chloropropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

: 1403934-24-6
methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Guidance literature:: With sodium azide; sodium iodide; In dimethylsulfoxide-d6; at 50 ℃; for 24h;
DOI:10.1021/jo301830j

Reference yield:

: 1403934-16-6
tert-butyl (RS,E) 5-(benzyloxy)dec-2-enoate

: 1403934-24-6
methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: thionyl chloride / 4 h / Reflux

3.1: sodium azide; sodium iodide / dimethylsulfoxide-d6 / 24 h / 50 °C

With n-butyllithium; thionyl chloride; sodium azide; sodium iodide; In tetrahydrofuran; dimethylsulfoxide-d6;
DOI:10.1021/jo301830j

Reference yield:

: 66-25-1
hexanal

: 1403934-24-6
methyl (3R,5S,αR)-3-[N-(3'-azidopropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

2.2: 18 h / 20 °C

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane; ethanol / 24 h / 40 °C

4.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 °C / Inert atmosphere

5.1: thionyl chloride / 4 h / Reflux

6.1: sodium azide; sodium iodide / dimethylsulfoxide-d6 / 24 h / 50 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; n-butyllithium; thionyl chloride; sodium azide; sodium hydride; sodium iodide; In tetrahydrofuran; dimethylsulfoxide-d6; ethanol; dichloromethane; mineral oil;
DOI:10.1021/jo301830j