(4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

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Chemical Name:(4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane
CAS No.:1404225-51-9
Molecular Formula:C₃₁H₅₂N₄O₃
Molecular Weight:528.779
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Chemical Property of (4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

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Technology Process of (4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

There total 8 articles about (4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1403934-32-6
(4R,2′S)-4-(2′-hydroxyheptyl)-N(5)-methyl-1,5-diazocan-2-one

: 1403934-35-9
(S)-N(1)-(4′-bromobutyl)-4-phenyl-N(5)-methyl-1,5-diazocan-2-one

: 1404225-51-9
(4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1021/jo301830j

Reference yield:

: 1403934-16-6
tert-butyl (RS,E) 5-(benzyloxy)dec-2-enoate

: 1404225-51-9
(4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: thionyl chloride / 4 h / Reflux

3.1: sodium azide; sodium iodide / dimethylsulfoxide-d6 / 24 h / 50 °C

4.1: tributylphosphine / tetrahydrofuran / 0.5 h / 20 °C

4.2: 2 h / 50 °C

5.1: triethoxyantimony / toluene / 18 h / Molecular sieve; Reflux

6.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

7.1: sodium cyanoborohydride / methanol / 18 h / 20 °C

8.1: potassium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / dimethyl sulfoxide / 48 h / 20 °C

With n-butyllithium; thionyl chloride; sodium azide; tributylphosphine; 10 wt% Pd(OH)2 on carbon; triethoxyantimony; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium cyanoborohydride; potassium carbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dimethylsulfoxide-d6; dimethyl sulfoxide; toluene; 4.1: |Staudinger Azide Reduction;
DOI:10.1021/jo301830j

Reference yield:

: 1403934-22-4
methyl (3R,5S,αR)-3-[N-(3′-chloropropyl)-N-(α-methylbenzyl)amino]-5-(benzyloxy)decanoate

: 1404225-51-9
(4′S,4''R,2'''S)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide; sodium iodide / dimethylsulfoxide-d6 / 24 h / 50 °C

2.1: tributylphosphine / tetrahydrofuran / 0.5 h / 20 °C

2.2: 2 h / 50 °C

3.1: triethoxyantimony / toluene / 18 h / Molecular sieve; Reflux

4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

5.1: sodium cyanoborohydride / methanol / 18 h / 20 °C

6.1: potassium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / dimethyl sulfoxide / 48 h / 20 °C

With sodium azide; tributylphosphine; 10 wt% Pd(OH)2 on carbon; triethoxyantimony; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium cyanoborohydride; potassium carbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; dimethylsulfoxide-d6; dimethyl sulfoxide; toluene; 2.1: |Staudinger Azide Reduction;
DOI:10.1021/jo301830j