5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside
• CAS No.: 875302-72-0
• Molecular Formula: C₄₀H₄₆N₂O₈Si
• Molecular Weight: 710.899

Synonyms:5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside

Chemical Property of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside

There total 1 articles about 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4,4'-dimethoxitrityl)-1'-(5-nitroindole)-D-riboside (875302-68-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside (875302-72-0) + 5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside (875302-74-2)

Guidance literature:

With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃;

Reference yield: 85.0%

5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside (875302-72-0) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside-3'-O-caynoethyl-N,N-diisopropylphosphoramidate (875302-76-4)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4 - 6h;

Reference yield:

succinic acid anhydride (108-30-5) + 5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside (875302-72-0) + 5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside (875302-74-2) → C44H50N2O11Si + C44H50N2O11Si

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 22h;

upstream raw materials:

5'-O-(4,4'-dimethoxitrityl)-1'-(5-nitroindole)-D-riboside

tert-butyldimethylsilyl chloride

Downstream raw materials:

5'-O-(4,4'-dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1'-(5-nitroindole)-D-riboside-3'-O-caynoethyl-N,N-diisopropylphosphoramidate

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