methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

Base Information

Chemical Name:methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}
CAS No.:1173180-36-3
Molecular Formula:C₂₂H₂₂N₄O₆
Molecular Weight:438.44
Hs Code.:

Synonyms:methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

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Chemical Property of methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

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Technology Process of methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

There total 4 articles about methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1173180-35-2
(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1173180-36-3
methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

Guidance literature:: (R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -20 ℃; for 0.25h; Inert atmosphere;

L-alanine methyl ester hydrochloride; In tetrahydrofuran; at -20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/cjoc.201400413

Reference yield:

: C₂₃H₂₃N₃O₇

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1173180-36-3
methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -78 - -20 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c3cc48833k

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1173180-36-3
methyl (S)-{2-[(R)-3-(1H-indol-3-yl)-2-(2-nitrobenzamido)propanamido]propanoate}

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 2 h / 0 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -20 °C / Inert atmosphere

2.2: 12 h / -20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; water;
DOI:10.1002/cjoc.201400413