tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

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Chemical Name:tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate
CAS No.:1432909-98-2
Molecular Formula:C₂₆H₂₇ClN₆O₃S
Molecular Weight:539.058
Hs Code.:

Synonyms:tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

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Chemical Property of tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

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Technology Process of tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

There total 5 articles about tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189532-29-3
tert-butyl (2-((5-formyl-2-(methylthio)pyrimidin-4-yl)amino)ethyl) carbamate

: 1432910-06-9
methyl 2-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)acetate

: 1432909-98-2
tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 1432909-98-2
tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / Reflux; Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1432909-98-2
tert-butyl (2-(6-(2-chloro-4-(6-methylpyrazin-2-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: manganese(IV) oxide / dichloromethane / Reflux; Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;