(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:207864-61-7
Molecular Formula:C₁₉H₂₉NO₃
Molecular Weight:319.444
Hs Code.:

Synonyms:(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

There total 6 articles about (2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 207864-59-3
(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine

: 207864-61-7
(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With piperidine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1055/s-1998-5928

Reference yield:

: 100-39-0
benzyl bromide

: 207864-61-7
(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / NaH / dimethylformamide

2: 1.) Mg, 2.) LiCuCl₄ / 1.) Et₂O, 30 min, 2.) THF, Et₂O, -78 deg C to r.t., overnight

3: 90 percent / zinc diazide bipyridine adduct, PPh₃, diisopropyl azodicarboxylate / toluene / 3 h

4: 1,2-dichloro-benzene / 3 h / 165 °C

5: LiAlH₄, Me₃Al / tetrahydrofuran; hexane / -78 - 0 °C

6: 97 percent / piperidine / CH₂Cl₂ / 0 - 20 °C

With piperidine; lithium aluminium tetrahydride; Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; lithium tetrachlorocuprate; trimethylaluminum; sodium hydride; magnesium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; toluene;
DOI:10.1055/s-1998-5928

Reference yield:

: 2930-05-4,14618-80-5,89616-40-0,16495-13-9
(S)-benzyl glycidyl ether

: 207864-61-7
(2R,6S)-2-Benzyloxymethyl-6-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg, 2.) LiCuCl₄ / 1.) Et₂O, 30 min, 2.) THF, Et₂O, -78 deg C to r.t., overnight

2: 90 percent / zinc diazide bipyridine adduct, PPh₃, diisopropyl azodicarboxylate / toluene / 3 h

3: 1,2-dichloro-benzene / 3 h / 165 °C

4: LiAlH₄, Me₃Al / tetrahydrofuran; hexane / -78 - 0 °C

5: 97 percent / piperidine / CH₂Cl₂ / 0 - 20 °C

With piperidine; lithium aluminium tetrahydride; Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; lithium tetrachlorocuprate; trimethylaluminum; magnesium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-benzene; toluene;
DOI:10.1055/s-1998-5928