N-(2,6-Dichlorophenyl)acetamidine

Base Information

• Chemical Name: N-(2,6-Dichlorophenyl)acetamidine
• CAS No.: 87349-75-5
• Molecular Formula: C8H8 Cl2 N2
• Molecular Weight: 203.071
• Hs Code.: 2925290090
• Mol file: 87349-75-5.mol

Synonyms:N-(2,6-Dichlorophenyl)acetamidine;N-(2-,6-Dichlorophenyl)ethanimidamide

Chemical Property of N-(2,6-Dichlorophenyl)acetamidine

Chemical Property:

• PSA: 35.88000
• LogP: 3.57520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,6-Dichlorophenyl)acetamidine

There total 1 articles about N-(2,6-Dichlorophenyl)acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

acetonitrile (75-05-8,26809-02-9) + 2,6-Dichloroaniline (608-31-1) → N-(2,6-dichlorophenyl)acetamidine (87349-75-5)

Guidance literature:

2,6-Dichloroaniline; With trimethylaluminum; In toluene; at 0 - 20 ℃; for 1h;

acetonitrile; In toluene; at 80 ℃; for 3h;

Reference yield: 58.0%

N-(2,6-dichlorophenyl)acetamidine (87349-75-5) + propynoic acid ethyl ester (623-47-2) → 3-(2,6-Dichloro-phenyl)-2-methyl-3H-pyrimidin-4-one (87356-59-0)

Guidance literature:

In ethanol; at 35 ℃; for 36h;

Reference yield: 43.0%

3-bromo-1,1,1-trifluoroacetone (431-35-6) + N-(2,6-dichlorophenyl)acetamidine (87349-75-5) → 1-(2,6-dichlorophenyl)-2-methyl-4-trifluoromethyl-1H-imidazole (1033586-34-3)

Guidance literature:

3-bromo-1,1,1-trifluoroacetone; N-(2,6-dichlorophenyl)acetamidine; With sodium hydrogencarbonate; In ethanol; for 1h;

With toluene-4-sulfonic acid; In toluene; at 105 ℃; for 15h;

upstream raw materials:

acetonitrile

2,6-Dichloroaniline

Downstream raw materials:

3-(2,6-dichlorophenyl)-2-methyl-6-phenyl-4(3H)-pyrimidinone

3-(2,6-Dichloro-phenyl)-2-methyl-3H-pyrimidin-4-one

1-(2,6-dichlorophenyl)-2-methyl-4-trifluoromethyl-1H-imidazole

2-bromomethyl-1-(2,6-dichlorophenyl)-4-trifluoromethyl-1H-imidazole

Refernces

• 1、 Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.,Srimal, R. C.,Kar, K.,Anand, Nitya. "Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones". . p. 384 - 387. Retrieved 2007/10/02.