N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

Base Information

Chemical Name:N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine
CAS No.:144181-33-9
Molecular Formula:C₁₉H₂₂ClNO₃
Molecular Weight:347.842
Hs Code.:

Synonyms:N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

Chemical Property:

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Technology Process of N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

There total 7 articles about N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 15893-42-2
3-(4-methoxyphenyl)propionyl chloride

: 96495-22-6
2-(4-chloro-3-methoxyphenyl)ethylamine

: 144181-33-9
N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: With triethylamine; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jm00101a018

Reference yield:

: 615-74-7
2-chloro-5-methylphenol

: 144181-33-9
N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / K₂CO₃ / acetone

2: 92 percent / KMnO₄ / pyridine; H₂O / 1.) 50 deg C, 24 h, 2.) RT, 13 h

3: 82 percent / LiAlH₄ / diethyl ether; dioxane

4: 93 percent / pyridinium chlorochromate / CH₂Cl₂

5: 89 percent / CH₃NH₂*HCl, Na₂CO₃ / ethanol / 72 h / Ambient temperature

6: 55 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

7: 62 percent / triethylamine / diethyl ether / 24 h / Ambient temperature

With potassium permanganate; lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; pyridine; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm00101a018

Reference yield:

: 13726-17-5
(4-chloro-3-methoxyphenyl)methan-1-ol

: 144181-33-9
N-<3-(4-methoxyphenyl)propionyl>-2-(4-chloro-3-methoxyphenyl)ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridinium chlorochromate / CH₂Cl₂

2: 89 percent / CH₃NH₂*HCl, Na₂CO₃ / ethanol / 72 h / Ambient temperature

3: 55 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

4: 62 percent / triethylamine / diethyl ether / 24 h / Ambient temperature

With lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00101a018