6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Base Information

• Chemical Name: 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile
• CAS No.: 83049-49-4
• Molecular Formula: C₂₀H₁₉N₅O
• Molecular Weight: 345.404

Synonyms:6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Chemical Property of 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile

There total 2 articles about 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Methyl-4-piperidone (1445-73-4) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-49-4,294663-15-3)

Guidance literature:

1-Methyl-4-piperidone; malononitrile; With pyrrolidine; In ethanol; for 0.00833333h; Sonication;

4-methoxy-benzaldehyde; In ethanol; for 0.00833333h; Sonication;

DOI:10.1016/j.tet.2016.02.023

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + butanedinitrile (110-61-2) + 4-methoxy-benzaldehyde (123-11-5) → 6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-49-4,294663-15-3)

Guidance literature:

In methanol;

Reference yield:

6-amino-8-(4-methoxyphenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile (83049-49-4,294663-15-3) → 6-Amino-8-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline-5,7-dicarbonitrile (83049-58-5)

Guidance literature:

With potassium hydroxide; In methanol; for 0.5h; Heating;

upstream raw materials:

1-Methyl-4-piperidone

butanedinitrile

4-methoxy-benzaldehyde

malononitrile

Downstream raw materials:

6-Amino-8-(4-methoxy-phenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline-5,7-dicarbonitrile

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