1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

Base Information

Chemical Name:1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine
CAS No.:854159-41-4
Molecular Formula:C₃₃H₃₆ClN₃O
Molecular Weight:526.121
Hs Code.:

Synonyms:1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

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Chemical Property of 1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

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Technology Process of 1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

There total 4 articles about 1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 854159-20-9
1-(2-chloro-4-pyridyl)-4-tritylpiperazine

: 630-19-3
pivalaldehyde

: 854159-41-4
1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

Guidance literature:: 1-(2-chloro-4-pyridyl)-4-tritylpiperazine; With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; toluene; at -20 ℃; for 2.5h;

pivalaldehyde; With iodine; In tetrahydrofuran; hexane; toluene; at -78 - 0 ℃;
DOI:10.1016/j.tet.2005.03.026

Reference yield:

: 854159-13-0
1-(4-pyridyl)-4-tritylpiperazine

: 854159-41-4
1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -5 °C

1.2: 89 percent / C₂Cl₆ / toluene; hexane; tetrahydrofuran / -78 - 0 °C

2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C

2.2: 61 percent / iodine / toluene; hexane; tetrahydrofuran / -78 - 0 °C

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; toluene;
DOI:10.1016/j.tet.2005.03.026

Reference yield:

: 76-83-5
trityl chloride

: 854159-41-4
1-(2-chloro-6-(2,2-dimethyl-1-hydroxypropyl)-4-pyridyl)-4-tritylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / triethylamine / dimethylformamide / 6 h / 100 °C

2.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -5 °C

2.2: 89 percent / C₂Cl₆ / toluene; hexane; tetrahydrofuran / -78 - 0 °C

3.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / -20 °C

3.2: 61 percent / iodine / toluene; hexane; tetrahydrofuran / -78 - 0 °C

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; triethylamine; In hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2005.03.026