4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate

Base Information

• Chemical Name: 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate
• CAS No.: 1333386-18-7
• Molecular Formula: C₇H₈O₃S*C₂₁H₁₅ClF₄N₄O₃
• Molecular Weight: 658.003
• Mol file: 1333386-18-7.mol

Synonyms:

Chemical Property of 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate

There total 17 articles about 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-amino-3-fluorophenoxy)-N-(methyl-d3)picolinamide (1257864-28-0) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 h / 20 °C

2: ethanol / 0.01 h / Reflux

In ethanol; dichloromethane;

Reference yield:

4-chloro-pyridine-2-carbonyl chloride (53750-66-6) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-18-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 5 h / 5 °C / Cooling with ice

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

2.2: 0.5 h / 100 °C

3.1: dichloromethane / 20 h / 20 °C

4.1: ethanol / 0.01 h / Reflux

With potassium tert-butylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

2-Picolinic acid (98-98-6) → 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate (1333386-18-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 72 °C

2.1: tetrahydrofuran / 5 h / 5 °C / Cooling with ice

3.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.33 h / 0 - 20 °C

3.2: 0.5 h / 100 °C

4.1: dichloromethane / 20 h / 20 °C

5.1: ethanol / 0.01 h / Reflux

With thionyl chloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;

upstream raw materials:

4-(4-amino-3-fluorophenoxy)-N-(methyl-d₃)picolinamide

4-chloro-pyridine-2-carbonyl chloride

2-Picolinic acid

4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide)