Technology Process of ethyl (methyl 4,5,7-tri-O-benzyl-3-deoxy-α-D-manno-2-octulopyranosid)onate
There total 8 articles about ethyl (methyl 4,5,7-tri-O-benzyl-3-deoxy-α-D-manno-2-octulopyranosid)onate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 4,5,7-tri-O-benzyl-3-deoxy-D-manno-2-octonate 1,3-propylene dithioketal; methanol;
With
3 A molecular sieve; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate;
In
dichloromethane;
at 0 ℃;
for 2.5h;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 0.5h;
DOI:10.1002/anie.200503299
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine / CH2Cl2 / 12 h / 20 °C
2.1: aq. NaOH; tetrabutylammonium sulfate / tetrahydrofuran / 24 h / 20 °C
3.1: 321 mg / camphorsulfonic acid / methanol; tetrahydrofuran / 6 h / 20 °C
4.1: 82 percent / imidazole; Ph3P; I2 / 0.25 h / 20 °C
5.1: NaH; tert-BuOH / dimethylformamide / 0 °C
5.2: dimethylformamide / 1 h / 20 °C
6.1: 545 mg / CSA / methanol / 12 h / 0 °C
7.1: 3 Angstroem molecular sieves; dimethyl(methylthio)sulfonium trifluoromethanesulfonate / CH2Cl2 / 2.5 h / 0 °C
7.2: 34 percent / trifluoroacetic acid / CH2Cl2 / 0.5 h / 0 °C
With
pyridine; 1H-imidazole; sodium hydroxide; 3 A molecular sieve; camphor-10-sulfonic acid; iodine; sodium hydride; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; tetrabutylammonium sulfate; triphenylphosphine; tert-butyl alcohol;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200503299
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 82 percent / imidazole; Ph3P; I2 / 0.25 h / 20 °C
2.1: NaH; tert-BuOH / dimethylformamide / 0 °C
2.2: dimethylformamide / 1 h / 20 °C
3.1: 545 mg / CSA / methanol / 12 h / 0 °C
4.1: 3 Angstroem molecular sieves; dimethyl(methylthio)sulfonium trifluoromethanesulfonate / CH2Cl2 / 2.5 h / 0 °C
4.2: 34 percent / trifluoroacetic acid / CH2Cl2 / 0.5 h / 0 °C
With
1H-imidazole; 3 A molecular sieve; camphor-10-sulfonic acid; iodine; sodium hydride; dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; triphenylphosphine; tert-butyl alcohol;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200503299
