N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide

Base Information

• Chemical Name: N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide
• CAS No.: 1265905-05-2
• Molecular Formula: C₂₄H₂₂N₂O₄S
• Molecular Weight: 434.516
• Mol file: 1265905-05-2.mol

Synonyms:N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide

Chemical Property of N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide

There total 2 articles about N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(3-bromophenyl)-N-methoxy-N-methylacetamide (866270-03-3) + 1-(phenylsulfonyl)-1H-indol-3-ylboronic acid (129271-98-3) → N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide (1265905-05-2)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; for 12h; Reflux; Inert atmosphere;

DOI:10.1002/anie.201004704

Reference yield:

3-Bromophenylacetic acid (1878-67-7) → N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide (1265905-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; XPhos / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

With dmap; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; water;

DOI:10.1002/anie.201004704

Reference yield: 58.0%

N-methoxy-N-methyl-2-(3-(1-(phenylsulfonyl)-1H-indol-3-yl)phenyl)acetamide (1265905-05-2) + Diphenyliodonium triflate (66003-76-7) → N-methoxy-N-methyl-2-(5-(1-(phenylsulfonyl)-1H-indol-3-yl)-[1,1'-biphenyl]-3-yl)acetamide

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 70 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201004704

upstream raw materials:

2-(3-bromophenyl)-N-methoxy-N-methylacetamide

1-(phenylsulfonyl)-1H-indol-3-ylboronic acid

3-Bromophenylacetic acid