Technology Process of (1R,4S,6S)-6-(tert-Butyldimethylsiloxy)-2-benzyl-2-azabicyclo<2.2.1>-3-heptanone
There total 10 articles about (1R,4S,6S)-6-(tert-Butyldimethylsiloxy)-2-benzyl-2-azabicyclo<2.2.1>-3-heptanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
1.) -50 to -35 deg C, 15 min, 2.) -35 deg C, 40 min;
DOI:10.1021/jo00119a044
- Guidance literature:
-
Multi-step reaction with 5 steps
1: imidazole / dimethylformamide / 15 h
2: 99 percent / NaH, TBAI / tetrahydrofuran / 1.) 15 min, 2.) 42 h
3: 100 percent / H2 / 10percent Pd/C / ethanol / 23 h
4: 93 percent / CBr4, PPh3 / CH2Cl2 / 1.) 0 deg C to r.t., 1 h, 2.) r.t., 13 h
5: 99 percent / KHMDS / tetrahydrofuran / 1.) -50 to -35 deg C, 15 min, 2.) -35 deg C, 40 min
With
1H-imidazole; carbon tetrabromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00119a044
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / NaH, TBAI / tetrahydrofuran / 1.) 15 min, 2.) 42 h
2: 100 percent / H2 / 10percent Pd/C / ethanol / 23 h
3: 93 percent / CBr4, PPh3 / CH2Cl2 / 1.) 0 deg C to r.t., 1 h, 2.) r.t., 13 h
4: 99 percent / KHMDS / tetrahydrofuran / 1.) -50 to -35 deg C, 15 min, 2.) -35 deg C, 40 min
With
carbon tetrabromide; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00119a044
