dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

Base Information

Chemical Name:dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate
CAS No.:183280-00-4
Molecular Formula:C₂₉H₃₈IN₂O₈PSi
Molecular Weight:728.593
Hs Code.:

Synonyms:dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

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Chemical Property of dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

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Technology Process of dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

There total 3 articles about dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24630-67-9
hydroxymethyl-phosphonic acid dimethyl ester

: 183279-94-9
1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)thymine

: 183280-00-4
dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

: dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-α-L-threo-pentofuranos-4-yloxy)methylphosphonate

Guidance literature:: With N-iodo-succinimide; In dichloromethane; at 20 ℃; Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2007.03.059

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 183280-00-4
dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / imidazole / dimethylformamide / 20 °C

2: NIS / CH₂Cl₂ / 20 °C

With 1H-imidazole; N-iodo-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.059

Reference yield:

: 28034-72-2
1-((2R,4S)-4-hydroxy-5-methylenetetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

: 183280-00-4
dimethyl (3-O-tert-butyldiphenylsilyl-5-iodo-1-thymin-1-yl-1,2,5-trideoxy-β-D-erythro-pentofuranos-4-yloxy)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / imidazole / dimethylformamide / 20 °C

2: NIS / CH₂Cl₂ / 20 °C

With 1H-imidazole; N-iodo-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.03.059