4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Base Information

Chemical Name:4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon
CAS No.:154770-68-0
Molecular Formula:C₂₇H₂₃F₃N₂O
Molecular Weight:448.488
Hs Code.:

Synonyms:4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Suppliers and Price of 4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

There total 5 articles about 4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 40862-32-6
1-iodo-3-(p-fluorophenylcarbonyl)propane

: 154770-67-9
6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol

: 154770-68-0
4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Guidance literature:: With sodium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;
DOI:10.1002/ardp.19933261206

Reference yield:

: 110977-75-8
3-(4-Fluorphenylhydrazono)-5,6-dihydro-pyran-2(4H)-on

: 154770-68-0
4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / 5percent HCl / acetic acid / 0.17 h / Heating

2: 83 percent / 8 h / 205 - 210 °C

3: 93 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 30 min, 2.) reflux, 3 h

4: 45 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidone-2 / 8 h / 185 - 195 °C

5: 88 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 750.06 - 1500.1 Torr / Ambient temperature

6: 60 percent / Na₂CO₃ / dimethylformamide / 3 h / 60 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19933261206

Reference yield:

: 110977-88-3
6-Fluor-4,9-dihydro-pyrano<3,4-b>indol-1(3H)-on

: 154770-68-0
4-<6-Fluor-9-(4-fluorphenyl)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indol-2-yl>-1-(4-fluorphenyl)-1-butanon

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 8 h / 205 - 210 °C

2: 93 percent / LiAlH₄ / tetrahydrofuran / 1.) r.t., 30 min, 2.) reflux, 3 h

3: 45 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidone-2 / 8 h / 185 - 195 °C

4: 88 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 750.06 - 1500.1 Torr / Ambient temperature

5: 60 percent / Na₂CO₃ / dimethylformamide / 3 h / 60 °C

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; lithium aluminium tetrahydride; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19933261206