benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

Base Information

Chemical Name:benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate
CAS No.:1357928-22-3
Molecular Formula:C₂₄H₂₈N₆O₈
Molecular Weight:528.522
Hs Code.:

Synonyms:benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

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Chemical Property of benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

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Technology Process of benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

There total 3 articles about benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1357928-21-2
benzyl ((((2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

: 1357928-22-3
benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

Guidance literature:: With dichloro-acetic acid; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1016/j.ejmech.2013.10.036

Reference yield:

: 68892-41-1
5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

: 1357928-22-3
benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h

3: dichloro-acetic acid / dichloromethane / 0.25 h

With dichloro-acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1357928-20-1
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl) tetrahydrofuran-3-yl-1H-imidazole-1-carboxylate

: 1357928-22-3
benzyl ((((2R,3S,5R)-2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)carbonyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h

2: dichloro-acetic acid / dichloromethane / 0.25 h

With dichloro-acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane;