(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

Base Information

Chemical Name:(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide
CAS No.:929693-07-2
Molecular Formula:C₂₆H₃₅NO₇
Molecular Weight:473.566
Hs Code.:

Synonyms:(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

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Technology Process of (2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

There total 5 articles about (2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 929693-24-3
(2R,4S)-methyl 2-(3,4-dimethoxybenzyloxy)-4-(4-methoxybenzyloxy)hept-6-enoate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 929693-07-2
(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; benzene; at -13 ℃; for 45h;
DOI:10.1002/anie.200603653

Reference yield:

: 929693-21-0
((2R,4S)-2-(3,4-dimethoxybenzyloxy)-4-(4-methoxybenzyloxy)hept-6-enyloxy)triisopropylsilane

: 929693-07-2
(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / tert-butylammonium fluoride / tetrahydrofuran / 2 h / 0 °C

2: 95 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / -15 °C

3: 1.04 g / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0 - 20 °C

4: 97 percent / benzene; methanol

5: 92 percent / i-PrMgCl / tetrahydrofuran; benzene / 45 h / -13 °C

With sodium chlorite; sodium dihydrogenphosphate; tert-butyl-ammonium fluoride; 2-methyl-but-2-ene; isopropylmagnesium chloride; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol; benzene;
DOI:10.1002/anie.200603653

Reference yield:

: 929693-22-1
(2R,4S)-2-(3,4-dimethoxybenzyloxy)-4-(4-methoxybenzyloxy)hept-6-en-1-ol

: 929693-07-2
(2R,4S)-2-(3,4-dimethoxybenzyloxy)-N-methoxy-4-(4-methoxybenzyloxy)-N-methylhept-6-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide; CH₂Cl₂ / 1 h / -15 °C

2: 1.04 g / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0 - 20 °C

3: 97 percent / benzene; methanol

4: 92 percent / i-PrMgCl / tetrahydrofuran; benzene / 45 h / -13 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; isopropylmagnesium chloride; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol; benzene;
DOI:10.1002/anie.200603653