N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

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Chemical Name:N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide
CAS No.:186095-70-5
Molecular Formula:C₂₁H₂₈F₃NO₃Si
Molecular Weight:427.539
Hs Code.:

Synonyms:N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

There total 8 articles about N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 186095-58-9
1-[11-(tert-Butyl-dimethyl-silanyloxy)-3-oxa-2-aza-bicyclo[9.2.2]pentadec-1⁽¹⁴⁾-ene-5,9-diyn-2-yl]-2,2,2-trifluoro-ethanone

: 186095-48-7
11-(tert-Butyl-dimethyl-silanyloxy)-3-oxa-2-aza-bicyclo[9.2.2]pentadec-1-ene-5,9-diyne

: 186095-70-5
N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

Guidance literature:: With Li-tetramethylpiperidide; In tetrahydrofuran; hexane; at -30 ℃; for 1h;

Reference yield:

: 41879-39-4
O-(tert-butyldimethylsilanyl)hydroxylamine

: 186095-70-5
N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 4 Angstroem molecular sieves / CH₂Cl₂ / Ambient temperature

2: TBAF*3H₂O / tetrahydrofuran / 0.33 h / 20 °C

3: LiBr / acetone / 48 h / 30 °C

4: 79 percent / NaH/paraffin / tetrahydrofuran / 36 h / Ambient temperature; several drops of water

5: 89 percent / CH₂Cl₂ / 2.5 h / Ambient temperature

6: 14 percent / Li-tetramethylpiperidide / tetrahydrofuran; hexane / 1 h / -30 °C

With 4 A molecular sieve; Li-tetramethylpiperidide; tetrabutyl ammonium fluoride; sodium hydride; lithium bromide; paraffin; In tetrahydrofuran; hexane; dichloromethane; acetone;

Reference yield:

: 186095-56-7
4-(7-Bromo-hepta-1,5-diynyl)-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone

: 186095-70-5
N-[4-(tert-Butyl-dimethyl-silanyloxy)-4-(7-oxo-hepta-1,5-diynyl)-cyclohex-1-enyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / H₂N-OH*HCl, NaOAc / methanol / 2 h / 0 °C

2: 79 percent / NaH/paraffin / tetrahydrofuran / 36 h / Ambient temperature; several drops of water

3: 89 percent / CH₂Cl₂ / 2.5 h / Ambient temperature

4: 14 percent / Li-tetramethylpiperidide / tetrahydrofuran; hexane / 1 h / -30 °C

With Li-tetramethylpiperidide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; paraffin; In tetrahydrofuran; methanol; hexane; dichloromethane;